Autism spectrum disorders have been associated with over 300 genetic mutations. As a polygenic disease, ASDs require at least one additional insult in addition to the underlying genetic susceptibility in order for manifestation of the disease phenotype (Caldwell, 2010). This work was funded by the M.J. Murdock Charitable Trust and private donations.
We were able to validate published data demonstrating the association of the degenerate 13 mer with meiotic recombination. The closer a 13 mer was to the middle of a recombination hotspot, the higher the recombination rate at that hotspot. However, binding scores for the constrained 13 mers did not demonstrate any relationship with meiotic recombination.
Impact of environmental factors on the prevalence of autistic disorder after 1979 (Journal of Public Health and Epidemiology)
The aim of this study was to investigate a previously overlooked, universally introduced environmental factor, fetal and retroviral contaminants in childhood vaccines, absent prior to change points in autistic order prevalence with subsequent dose-effect evidence and known pathologic mechanism of action.