Unstable Gene Sites Are Concentrated in Autism Associated Genes
We were able to validate published data demonstrating the association of the degenerate 13 mer with meiotic recombination. The closer a 13 mer was to the middle of a recombination hotspot, the higher the recombination rate at that hotspot. However, binding scores for the constrained 13 mers did not demonstrate any relationship with meiotic recombination.
Applying Atomistic Modeling to Predict NLGN3 Isoform Binding to Neurexin 1- Beta
Autism spectrum disorders have been associated with over 300 genetic mutations. As a polygenic disease, ASDs require at least one additional insult in addition to the underlying genetic susceptibility in order for manifestation of the disease phenotype (Caldwell, 2010). This work was funded by the M.J. Murdock Charitable Trust and private donations.
Spontaneous Integration of Human DNA Fragments into Host Genome
Not only damaged human cells, but also healthy human cells can take up foreign DNA spontaneously. Foreign human DNA taken up by human cells will be transported into nuclei and be integrated into host genome, which will cause phenotype change. Hence, residual human fetal DNA fragments in vaccine can be one of causes of autism spectrum disorder in children through vaccination. Vaccine must be safe without any human DNA contaminations or reactivated viruses, and must be produced in ethically approved manufacturing processes.
Sociological Environmental Causes are Insufficient to Explain Autism Changepoints of Incidence
This study confirms the 1988 changepoint detected by EPA and adds 1981 and 1996 as additional changepoints. AD birthyear changepoints, particularly 1981 and 1996, cannot be explained by predicted birthyear changepoints based on altered thimerosal content in vaccines nor on revised editions of the DSM. Based on changepoint anaylses, environmental factors introduced universally to children in the US according to the schedule in the table below should be investigated. A prime environmental suspect is the introduction of human DNA contaminants in vaccines introduced to the US in 1979-1983, 1989 and 1995.
Impact of environmental factors on the prevalence of autistic disorder after 1979 (Journal of Public Health and Epidemiology)
The aim of this study was to investigate a previously overlooked, universally introduced environmental factor, fetal and retroviral contaminants in childhood vaccines, absent prior to change points in autistic order prevalence with subsequent dose-effect evidence and known pathologic mechanism of action.
Epidemiologic and Molecular Relationship Between Vaccine Manufacture and Autism Spectrum Disorder Prevalence
Changepoint analysis of autism disorder demonstrates a temporal correlation with events associated with human DNA residuals in vaccines. The levels of residual DNA are well over FDA-recommended limits.